New learning discoveries about 201341-05-1

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 201341-05-1, you can contact me at any time and look forward to more communication. Product Details of 201341-05-1.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Product Details of 201341-05-1, 201341-05-1, Name is Tenofovir disoproxil, SMILES is O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O, in an article , author is Kadi, Adnan A., once mentioned of 201341-05-1.

LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways

Brigatinib (BGB) is a newly approved anaplastic lymphoma kinase (ALK) inhibitor. On April 28, 2017, BGB was approved by the U.S. FDA for the treatment of metastatic anaplastic lymphoma kinase-positive non-small cell lung cancer. The toxicity profile of BGB includes nausea, fatigue, diarrhea, elevated lipase, dyspnoea, hypertension, hypoxia, pneumonia, elevated amylase, pulmonary embolism, elevated ALT, hyponatraemia and hypophosphatemia. Using LC-MS/MS, we investigated the in vitro phase I metabolism of for BGB in rat liver microsomes (RLMs). In the in vitro metabolism of BGB, iminium reactive intermediates were trapped by potassium cyanide forming a stable complex that can be characterized by LC-MS/MS. Four BGB in vitro phase I metabolites were identified. In vitro phase I metabolic pathways were N-dealkylation, alpha hydroxylation and alpha oxidation. Additionally, three iminium reactive metabolites were found and the bioactivation mechanisms were proposed. A piperidine ring was found to be responsible for BGB bioactivation. The presence of these three reactive metabolites may be the main reason for BGB side effects. A literature review showed no previous article reported the in vitro phase I metabolism study of BGB or structural identification of the formed reactive metabolites.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 201341-05-1, you can contact me at any time and look forward to more communication. Product Details of 201341-05-1.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem