With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19365-08-3,3-Hydroxypiperidin-2-one,as a common compound, the synthetic route is as follows.
To a suspension of 3-hydroxy-piperidin-2-one (500 mg, 4.34 mmol, 1.0 eq) and triethylamine (0.908 mL, 6.51 mmol, 1.5 eq) in dichloromethane (3 mL) at 0 C was added dropwise methanesulfonyl chloride (497 mg, 4.34 mmol, 1.0 eq) dissolved in dichloromethane (1 mL). The reaction was complete within 30 min as judged by LCMS. An orange precipitate was filtered, redissolved in dichloromethane and purified by column chromatography (MeOH/CH2Cl2) to give the title compound as a white waxy solid (204 mg, 1.056 mmol, 24.3% yield). 1 H NMR (400 MHz, chloroform-d) delta ppm 5.78 (br. s, 1 H) 4.94 – 5.05 (m, 1 H) 3.30 – 3.44 (m, 2 H) 3.27 (s, 3 H) 2.24 – 2.37 (m, 1 H) 2.08 – 2.21 (m, 1 H) 1 .98 – 2.08 (m, 1 H) 1 .79 – 1 .96 (m, 1 H). MS (m/z, MH+): 193.7., 19365-08-3
The synthetic route of 19365-08-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NOVARTIS AG; CHEN, Christine Hiu-Tung; CHIN, Noel Chin; DIPIETRO, Lucian V.; FAN, Jianme; PALERMO, Mark G; SHULTZ, Michael David; TOURE, Bakary-Barry; WO2013/8217; (2013); A1;,
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