With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184637-48-7,tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 3-((terf-butoxycarbonyl)amino)piperidine (400 mg, 2.0 mmol) in DCM (10 mL) was added triethylamine (0.50 mL, 3.6 mmol) followed by methyl chloroformate (0.20 mL, 2.6 mmol). After stirring overnight, the reaction was concentrated, diluted with EtOAc and washed with 0.5 N HCI, water and brine. The organic layer was dried over sodium sulfate, filtered and concentrated to afford the title compound as a white solid (502 mg, 97percent yield). 1H NMR (400 MHz, CD3SOCD3) delta 1 .27-1 .35 (m, 2 H), 1 .38 (s, 9 H), 1 .62-1 .69 (m, 1 H), 1 .72-1 .80 (m, 1 H), 2.74-2.83 (m, 1 H), 3.20-3.28 (m, 1 H), 3.52-3.58 (m, 1 H), 3.58 (s, 3 H), 3.66-3.74 (m, 1 H), 3.76-3.89 (m, 1 H), 6.85-6.91 (m, 1 H)., 184637-48-7
The synthetic route of 184637-48-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, David Norman; GUO, Yu; HANCOCK, Ashley Paul; SCHULTE, Christie; SHEARER, Barry George; SMITH, Emilie Despagnet; STEWART, Eugene L.; THOMSON, Stephen Andrew; (556 pag.)WO2018/69863; (2018); A1;,
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