163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 6-chloro-3-(2,3-dichlorophenyl)pyrazine-2-carbonitrile (50 mg, 176 mupiiotaomicron, 1 equiv) and ter/-butyl(4-methylpiperidin-4-yl)carbamate (56.5 mg, 264 mupiiotaomicron, 1.5 equiv) in dioxane (1 mL) and DIPEA (1 mL) was warmed to 120 C and stirred for 2 hours. The mixture was then concentrated under reduced pressure to give ter/-butyl(l-(6-cyano-5-(2,3- dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)carbamate (80 mg, crude) as a yellow oil which was used directly in the next step without further purification. LC-MS (ESI): m/z: [M + H] calculated for C22H25C12N502: 462.14; found 462.0., 163271-08-7
The synthetic route of 163271-08-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
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