159635-22-0, tert-Butyl 3-hydroxy-4-methylenepiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2) 1-t-Butoxycarbonyl-3,4-didehydro-4-(chloromethyl)piperidine To 1-t-butoxycarbonyl-3-hydroxy-4-methylenepiperidine (5.329 g, 25.1 mmol) in toluene (120 mL) and 2,6-lutidine (3.1 mL, 26 mmol) at 0 C. was added SOCl2 (2.0 mL, 26 mmol). The reaction was heated at 40 C. for 30 min, cooled to 0 C., washed with 0 C. 1N HCl (100 mL), 0.1 N HCl (100 mL), H2 O (100 mL), brine (50 mL), dried (MgSO4), and concentrated in vacuo to afford 5.18 g (89%) of allylic chloride as a yellow oil. 1 H NMR (400 MHz, CDCl3) delta 5.78 (s, 1H), 4.04 (s, 2H), 3.95 (s, 2H), 3.55 (t, 2H, J=6 Hz), 2.24 (s, 2H), 1.45 (s, 9H) ppm.
159635-22-0, The synthetic route of 159635-22-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Merck & Co., Inc.; US6013652; (2000); A;,
Piperidine – Wikipedia
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