157327-41-8, 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2,2-Dimethyl-1 -(2-(methylsulfonyl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)- yl)propan-1-one[00138]To a solution of crude fe/f-butyl 3-((dimethylamino)methylene)-4-oxopiperidine- 1 -carboxylate (see Preparation 2) (10.70 g, 42.1 mmol) and methyl carbamimidothioate hemisulfate (14.05 g, 50.5 mmol, 1 .2 eq.) in DMSO (200 ml_) is added 4M HCI solution in dioxane (1 .1 ml_, 4.2 mmol, 0.1 eq.). The mixture is heated at 130 C overnight. After cooling down to room temperature EtOAc (330 ml_) and DEE (660 ml_) are added, and the organic layer is washed with water (1 L), brine (3 x, each 1 L), dried over Na2S04, and concentrated in vacuo. Purification by flash column chromatography (silica, gradient 100% heptane to 40% EtOAc/heptane) affords 4.6 g (35%, purity 90%) of theintermediate product fe/f-butyl 2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5/-/)- carboxylate., 157327-41-8
The synthetic route of 157327-41-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERZ PHARMA GMBH & CO. KGAA; ABEL, Ulrich; KRUEGER, Bjoern; KUBAS, Holger; MEYER, Udo; ZEMRIBO, Ronalds; SMITS, Gints; WO2012/85167; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem