149554-03-0, tert-Butyl 2-(4-oxopiperidin-1-yl)acetate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To the solution of piperidin-4-one (10 mmol) inTHF (20 mL) was added tert-Butyl bromoacetate (11 mmol), and the mixture was stirredfor 4 h. The mixture was poured to H20 and extracted with EtOAc (3X). The combined organic was washed with brine, dried with Na2504. The solvent was removed under vacuum to afford the crude amineketone, which was used for next step without purification. To the suspension of crude amineketone (1 mmol) in CH2C12 was addedm-CPBA (2 mmol) at 0 C. The mixture was stirred for 8 h at room temp. The aqueous Na2 S203 was added and the mixture was extracted with CH2C12, washed with brine and dried with Na2504. The solvent was removed under vacuum, and the residual was purified with flash column (MeOH : CH2C12 1:4) to give desired lactone (40% for 3 steps).?H NMR (400 MHz, CDC13) 1.47 (s, 9H), 2.52 (t, J = 7.9 Hz, 2H), 2.94 t, J =7.9 Hz, 2H), 3.26 (s, 2H), 3.80 (m, 2H), 4.25 (m, 2H).
149554-03-0, The synthetic route of 149554-03-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; UNIVERSITY OF WASHINGTON; JIANG, Shaoyi; BAI, Tao; ELLA-MENYE, Jean-Rene; HUNG, Hsiang-Chieh; JAIN, Priyesh; SINCLAIR, Andrew; SUNDARAM, Harihara Subramanian; LI, Yang; ZHANG, Peng; (98 pag.)WO2017/3639; (2017); A2;,
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