With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.
To a solution of 0.50 g (2.62 mmol) of rac-2 in 1 ml of dry pyridine cooled to 0 C, 0.35 ml (3.70 mmol) of acetic anhydride was added under nitrogen. The resulting mixture was stirred overnight at room temperature. The reaction mixture was diluted with toluene (3 x 3 ml) and concentrated under reduced pressure to give 0.57 g (2.45 mmol) of rac-4 as a pale yellow oil (94% yield). 1H NMR (300 MHz, CDCl3, d ppm): 1.46-1.94 (m, 4H); 2.04 (s,3H); 2.10-2.21 (m, 2H); 2.45-2.79 (m, 2H); 3.57 (s, 2H); 4.84 (s,1H); 7.22-7.45 (m, 5H); TLC Rf = 0.59.
14813-01-5, 14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Tofani, Giorgio; Petri, Antonella; Piccolo, Oreste; Tetrahedron Asymmetry; vol. 26; 12-13; (2015); p. 638 – 643;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem