With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143900-43-0,(R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
A mixture oftert-butyl (R)-3-hydroxypiperidine-l-carboxylate (5.15 g, 25 mmol) and Et3N (7.6 g, 77 mmol) in DCM (50 mL) was stirred at 0 C, MsCl (5.8 g, 52 mmol) was added to solution in dropwise, keep stirred for 3 h. The solvent was washed by saturated aqueous NaHC03 (50 mL 2) then brine (50 mL), dried over Na2S04, purified by flash chromatography on silica gel (DCM: 100%) to afford product as yellow solid, 3.06 g. ESI-MS m/z 280 (MH)+.
The synthetic route of 143900-43-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher, J.; CHU, Guo-Hua; HAMRICK, Jodie; BOYD, Steven, A.; CONDON, Stephen, M.; (0 pag.)WO2019/232053; (2019); A1;,
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