With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142851-03-4,Ethyl N-Boc-piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.
To 1-tert-butyl 4-ethyl piperidine-1, 4-dicarboxylate (4.96 g, 19.3 ?tmol) in methanol (20 mL) was added hydrazine hydrate (5 mL) and the mixture was heated to reflux for 3 days . The mixture was concentrated to dryness to give tert- butyl 4- (hydrazinocarbonyl)piperidine-l-carboxylate as a white crystalline solid (4.2 g, 90%) : 1H NMR (400 MHz, DMSO-d6) delta1.39 (s, 9H), 1.39-1.42 (m, 2H), 1.55-1.64 (m, 2H), 2.18-2.27 (in, IH), 2.63-2.76 (m, 2H), 3.89-3.97 (m, 2H), 9.03 (br, IH); m/z (APCI pos) 144.1 (100%) [M+H-Boc] .
142851-03-4, The synthetic route of 142851-03-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/11130; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem