138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(E)-3-(4-Chloro-2-((5-methyl-2 H-tetrazol-2-yl) methyl)phenyl)acrylic acid (Intermediate A)(200 mg, 0.718 mmol) and tert-butyl 4-((methylamino)methyl)piperidine-1-carboxylate (154mg, 0.718 mmol) were dissolved in DMF (3 ml). DIPEA (501 ul, 2.87 mmol) was added followed by 50percent T3P? solution in DMF (838 ul, 1.435 mmol) and the mixture was stirred at room temperature overnight. The resulting mixture was concentrated in vacuo. The residue was dissolved in EtOAc and washed with 10percent citric acid, saturated bicarbonate solution,brine, dried over MgSO4, filtered and concentrated in vacuo. Purification by chromatography on silica eluting with a gradient of EtOAc in iso-hexane afforded the title compound; LCMS: Rt 1.26 mins MS mlz 389.5 [M+H-Boc]+ Method 2minLowpHvol., 138022-02-3
138022-02-3 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate 21934652, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; BAETTIG, Urs; BEATTIE, David; LEGRAND, Darren Mark; LISTER, Andrew Stuart; MCKENNA, Jeffrey; PEARCE, David William; SANDHAM, David Andrew; STANLEY, Emily; STEWARD, Oliver Ross; THOMSON, Christopher; WO2015/8229; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem