138007-24-6, tert-Butyl piperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
tert-Butyl piperidine-4-carboxylate (2.84 g, 15.33 mmol) and 2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)acetaldehyde(4.05 g, 22.99 mmol) were dissolved in DCE (120m1) then sodium triacetoxyborohydride (9.75 g, 46.0 mmol) was added and and the mixtue was stirred for 16 hrs. The reaction mixture was poured into aqueous NaHCO3 solution and extractedwith DCM. The organic layer was separated and dried over Na2504, filtered and concentrated. The crude residue was chromatographed through a 330g ISCO Redi-sep column and eluted with 5percent (NHOH: MeOH 1:9) in 95percent DCM to yield tert-butyl 1-(2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)ethyl)piperidine-4-carboxylate. LC-MS (IE, m/z): 346 [M + 1]¡À; lHNMR (500 MHz, CDC13) oe ppm 7.859 (d, J= 7.9 Hz, 1H), 7.394 (d, J= 8.0 Hz, 1H), 7.352 (s,1H), 5.311 (s, 2H), 2.965 (b, 4H), 2.641 (b, 2H), 2.234 (b, 1H), 2.139 (b, 2H), 1.925(d, J 9.5 Hz, 2H), 1 .788( t, J 11.5 Hz, 2H,) 1.447 (s, 9H)., 138007-24-6
138007-24-6 tert-Butyl piperidine-4-carboxylate 1512676, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; TANG, Haifeng; FRIE, Jessica; FERGUSON, Ronald Dale; GUO, Zhiqiang; SHI, Zhi-Cai; CATO, Brian; FU, Qinghong; WO2015/65866; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem