1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation 47: 7-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4,5]decan-1-one (P47)Chlorobis(4-fluorophenyl)methane (0.174 m L, 0.934 mmol) was added to a stirred mixture of 2,7- diazaspiro[4.5]decan-l-one hydrochloride salt (0.15 g, 0.78 mmol) and K2C03(0.27 g, 1.95 mmol) in Acetonitrile (3 m L). The mixture was stirred for 3 hrs at reflux. The solution was diluted with EtOAc and water. The organic phase was dried and evaporated. The residue was purified by FC on silica gel (eluent: cHex to EtOAc) to afford 7-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4.5]decan-l-one (p47, 165 mg, y= 59%) as white foam .MS (ES) (m/z): 357.2 [M+H]+.
1187173-43-8, 1187173-43-8 2,7-Diazaspiro[4.5]decan-1-one hydrochloride 45074126, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; SHIRE INTERNATIONAL GMBH; SEMERARO, Teresa; TARSI, Luca; MICHELI, Fabrizio; LUKER, Tim; CREMONESI, Susanna; (122 pag.)WO2016/42451; (2016); A1;,
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