1104083-27-3, tert-Butyl 3-hydroxy-3-methylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tert-butyl 3-hydroxy-3-methylpiperidine-i-carboxylate (0.10 g, 0.46 mmol)in dry DMF (1 mL) under argon atmosphere was added sodium hydride (60% suspension, 0.027 g, 0.69 mmol, 1.5 equiv) at 0 C. The reaction was warmed to room temperature and stirred for 10 mm; 3-(trifluoromethyl)-i-fluorobenzene (0.084 g, 0.511 mmol, 1.1 equiv) was added at 0 C. The reaction mixture was heated at 100 C in sealed tube for 16 h. After completion, the reaction was diluted with water and extracted with ethyl acetate. The organicextract was dried over sodium sulfate, filtered and concentrated under reduced pressure.Purification using silica gel column chromatography (20% EtOAc Hexanes as eluent) toafford 0.065 g of tert-butyl 3-methyl-3-(3-(trifluoromethyl)phenoxy)piperidine- 1-carboxylate(Yield = 39%)., 1104083-27-3
1104083-27-3 tert-Butyl 3-hydroxy-3-methylpiperidine-1-carboxylate 57416953, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; DORDEVIC, Luka; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (425 pag.)WO2016/100940; (2016); A1;,
Piperidine – Wikipedia
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