1039741-54-2, 1-Benzyl-3,3-difluoropiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Di-tert-butyl dicarbonate (1.19 g, 5.44 mmol) was added to a solution of i-benzyl-3,3-difluoropiperidin-4-one (995mg, 4.42 mmol) in EtCH (60 mL) under nitrogen.Palladium hydroxide (Pd 20% on carbon, 148 mg, 1.05mmol) was added and the system was evacuated andflushed with hydrogen several times. The mixture was stirred at RT for 20 h under hydrogen. The residual hydrogen was removed and the mixture was filtered over Celite, and washed with EtCH. Purification gave titled compound (810 mg, 3.44 mmol, 78% yield) as a white solid.1H NMR (400 MHz, DMSC-d6, ): 3.66-3.52 (m, 2H), 3.39-3.33 (m, 2H), 1.69-i .64 (m, 2H), 1.38 (5, 9H)
1039741-54-2, 1039741-54-2 1-Benzyl-3,3-difluoropiperidin-4-one 49761227, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; REDX PHARMA PLC; GUISOT, Nicolas; (266 pag.)WO2017/103611; (2017); A1;,
Piperidine – Wikipedia
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