With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
General procedure: Appropriate 2-((5-substitutedbenzothiazol-2-yl)thio) acetohydrazide (3a-3b) (0.002 mol), 4-substitutedbenzaldehyde (0.002 mol) and glacial acetic acid (0.1 mL) were refluxed in EtOH for 2 h. The mixture was cooled down in an ice-bath, precipitated product was filtered, dried and recrystallized from EtOH. 2-((5-Chlorobenzothiazol-2-yl)thio)-N?-(4-(piperidin-1-yl)benzylidene)acetohydrazide (4a). Yield: 83%, M.P. =178-179 C, FTIR (ATR, cm-1): 3277 (N-H), 1654 (C=O), 1232 (C-N), 1022, 813, 794. 1H-NMR (300 MHz,DMSO-d6): delta= 1.57 (6H, br.s, piperidine), 3.25 (4H, br.s, piperidine), 4.66 (2H, s, -CH2-), 6.91 (2H, d,J = 8.86 Hz, Ar-H), 7.42 (1H, dd, J1 = 2.10 Hz, J2 = 8.55 Hz, BT-H), 7.49 (2H, d, J = 8.86 Hz, Ar-H), 7.91(1H, s, -CH=N-), 7.93 (1H, d, J = 2.10 Hz, BT-H), 8.05 (1H, d, J = 8.55 Hz, BT-H), 11.52 (1H, s, -NH). 13C-NMR (75 MHz, DMSO-d6): delta = 24.4, 25.4, 35.8, 48.9, 115.0, 121.1, 123.7, 124.9, 128.6, 131.7, 134.0, 144.9, 148.2, 152.8, 153.9, 162.7, 168.1. HRMS (m/z): [M + H]+ calcd for C21H21N4OS2Cl: 445.0918; found: 445.0905., 10338-57-5
As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.
Reference：
Article; Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilg?n, Sinem; Zkay, Yusuf; Kaplancikli, Zafer Asim; Molecules; vol. 23; 5; (2018);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem