41979-39-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.41979-39-9, Name is Piperidin-4-one hydrochloride, molecular formula is C5H10ClNO. In a Article£¬once mentioned of 41979-39-9
Design and optimize N-substituted EF24 as effective and low toxicity NF-kappaB inhibitor for lung cancer therapy via apoptosis-to-pyroptosis switch
As NF-kappaB signaling pathway is constitutively activated in lung cancer, targeting NF-kappaB has a potential for the treatment. EF24 has been proved to be a NF-kappaB inhibitor with good antitumor activity, while whose toxicity possibly became one of the obstacles to enter into clinical application. In order to find high efficiency and low toxicity NF-kappaB inhibitors, EF24 was modified and 13d was screened out. It was proved that 13d possessed an effective combination of inhibiting NF-kappaB pathway and showing lower cytotoxicity on normal cells as well as less toxicity in acute toxicity experiment compared with the lead compound of EF24. In addition, 13d was found to inhibit cell vitality, arrest cell cycle in G2/M phase, promote cell apoptosis, and suppress the xenograft tumor growth. Furthermore, 13d was elucidated to induce pyroptosis developing from apoptosis, which was associated with the inhibition of NF-kappaB. Taken together, it was suggested that 13d was a potent antitumor agent.
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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H6154N – PubChem