Chemistry is an experimental science, Safety of 4-Piperidinoaniline, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2359-60-6, Name is 4-Piperidinoaniline
Discovery of N-aryl-N?-pyrimidin-4-yl ureas as irreversible L858R/T790M mutant selective epidermal growth factor receptor inhibitors
A novel series of N-aryl-N?-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the EGFR L858R/T790M. The most representative compound 28 showed high activity against EGFR L858R/T790M kinase (IC50 = 4 nM) and 22-fold selectivity against wild type EGFR. Moreover, compound 28 potently inhibited EGFR L858R/T790M phosphorylation (IC50 = 41 nM) and cellular proliferation (IC50 = 37 nM) in the H1975 cell line, while being significantly less toxic to A431 cells. Further, compound 28 exhibited a great selectivity in a mini-panel of kinases.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of 4-Piperidinoaniline, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2359-60-6, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H10631N – PubChem