Application of 1903-69-1, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1903-69-1, Name is N-Methylpiperidine-4-carboxamide, molecular formula is C7H14N2O. In a Article，once mentioned of 1903-69-1
Extensive optimization of quinazoline-based lead 8 is described. The structure-activity relationship studies indicate the S-configuration is preferred for the phenylmorpholine substitution. Together with incorporation of a (2-hydroxyl-2-methylpropyl)pyrazole moiety at the 2-position leads to analogs with comparable potency and marked improvement in the pharmacokinetic profile over our previously reported lead compounds. Further in vivo efficacy studies in Kasumi-1 xenograft mouse model demonstrates that the selected inhibitors are well tolerated and highly efficacious in the inhibition of tumor growth. Additionally, the representative analog 19 also demonstrated significant improvement of arthritis severity in a collagen-induced arthritis (CIA) mouse model. These results indicate potential use of these quinazoline-based BET inhibitors for treatment of cancer and inflammatory diseases. A brief discussion of the co-crystallized structure of 19 with BRD4 (BD1) is also highlighted.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 1903-69-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1903-69-1, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H6799N – PubChem