In an article, author is Harkiss, Alexander H., once mentioned the application of 41661-47-6, Name is Piperidin-4-one, molecular formula is C5H9NO, molecular weight is 99.1311, MDL number is MFCD00955709, category is piperidines. Now introduce a scientific discovery about this category, Recommanded Product: 41661-47-6.
Access to 2,6-Disubstituted 4-Oxopiperidines Using a 6-Endo-trig Cyclization: Stereoselective Synthesis of Spruce Alkaloid and (+)-241 D
A synthetic route to cis-2-methyl-4-oxo-6-alkylpiperidines has been developed using a 6-endo-trig cyclization of (E)-enones. The base-mediated intramolecular cyclization was found to be general for both alkyl- and aryl-substituted enones, providing the corresponding 4-oxopiperidines in high yields (8089%). Stereoselective reduction of the 2,6-cis-disubstituted 4-oxopiperidines then gave the 2,4,6-cis,cis-trisubstituted 4-hydroxypiperidines in high diastereoselectivity. The general nature of this approach was demonstrated with the synthesis of the natural products, spruce alkaloid and (+)-241D.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem