Reference of 41556-26-7, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, SMILES is O=C(OC1CC(C)(C)N(C)C(C)(C)C1)CCCCCCCCC(OC2CC(C)(C)N(C)C(C)(C)C2)=O, belongs to piperidines compound. In a article, author is Lazewska, Dorota, introduce new discover of the category.
Novel naphthyloxy derivatives – Potent histamine H-3 receptor ligands. Synthesis and pharmacological evaluation
A series of 1- and 2-naphthyloxy derivatives were synthesized and evaluated for histamine H-3 receptor affinity. Most compounds showed high affinities with K-i values below 100 nM. The most potent ligand, 1-(5-(naphthalen-1-yloxy) pentyl)azepane (11) displayed high affinity for the histamine H-3 receptor with a Ki value of 21.9 nM. The antagonist behaviour of 11 was confirmed both in vitro in the cAMP assay (IC50=312 nM) and in vivo in the rat dipsogenia model (ED50=3.68 nM). Moreover, compound 11 showed positive effects on scopolamine induced-memory deficits in mice (at doses of 10 and 15 mg/kg) and an analgesic effect in the formalin test in mice with ED50=30.6 mg/kg (early phase) and ED50=20.8 mg/kg (late phase). Another interesting compound, 1-(5-(Naphthalen-1-yloxy)pentyl)piperidine (13; H3R K-i=53.9 nM), was accepted for Anticonvulsant Screening Program at the National Institute of Neurological Disorders and Stroke/National Institute of Health (Rockville, USA). The screening was performed in the maximal electroshock seizure (MES), the subcutaneous pentylenetetrazole (scPTZ) and the 6-Hz psychomotor animal models of epilepsy. Neurologic deficit was evaluated by the rotarod test. Compound 13 inhibited convulsions induced by the MES with ED50 of 19.2 mg/kg (mice, i.p.), 17.8 (rats, i.p.), and 78.1 (rats, p.o.). Moreover, 13 displayed protection against the 6-Hz psychomotor seizures (32 mA) in mice (i.p.) with ED50 of 33.1 mg/kg and (44 mA) ED50 of 57.2 mg/kg. Furthermore, compounds 11 and 13 showed in vitro weak influence on viability of tested cell lines (normal HEK293, neuroblastoma IMR-32, hepatoma HEPG2), weak inhibition of CYP3A4 activity, and no mutagenicity. Thus, these compounds may be used as leads in a further search for histamine H3 receptor ligands with promising in vitro and in vivo activity. (C) 2018 Published by Elsevier Ltd.
Reference of 41556-26-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 41556-26-7.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem