Synthetic Route of 105812-81-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, SMILES is CN1C[C@@H](CO)[C@H](C2=CC=C(F)C=C2)CC1, belongs to piperidines compound. In a article, author is Bender, Aaron M., introduce new discover of the category.
Discovery and Optimization of Potent and CNS Penetrant M-5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold
The pharmacology of the M-5 muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the optimization effort around the prototypical M-5 positive allosteric modulator (PAM) ML380 and have discovered and optimized a new series of M-5 PAMs based on a chiral N-(indanyl)piperidine amide core with robust SAR, human and rat M-5 PAM EC50 values <100 nM and rat brain/plasma K-P values of similar to 0.40. Interestingly, unlike M, and M-4 PAMs with unprecedented mAChR subtype selectivity, this series of M-5 PAMs displayed varying degrees of PAM activity at the other two natively G(q)-coupled mAChRs, M, and M-3, yet were inactive at M-2 and M-4. Synthetic Route of 105812-81-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 105812-81-5 is helpful to your research.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem