On July 31, 1995, Nemeryuk, M. P.; Sedov, A. L.; Safonova, T. S.; Shvarts, G. Ya.; Faiermark, I. F.; Mashkovskii, M. D. published an article.COA of Formula: C9H13ClN4 The title of the article was Synthesis and pharmacological properties of 4(5)-substituted 5(4)-amidino-1,2,3-triazoles. And the article contained the following:
Title compounds I [R1 = R2 = Me; R1R2 = (CH2)5, (CH2)2O(CH2)2; R3 = Cl, MeO, PhCH2S, 3,4-Cl2C6H3CH2S] were prepared by diazotization of 4-(dialkylamino)-5-aminopyrimidines II in aqueous HCl. Triazole I [R1R2 = (CH2)2O(CH2)2; R3 = Cl] showed antihypertensive effect in rats at dose 10 mg/kg. It also showed low toxicity with LD50 > 1000 mg/kg. The experimental process involved the reaction of 4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine(cas: 84762-70-9).COA of Formula: C9H13ClN4
The Article related to amidinotriazole antihypertensive preparation, diazotization dialkylamino aminopyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C9H13ClN4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem