Reference of 2-(Piperidin-4-yl)ethanolIn 2012 ,《Synthesis and structure-activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Negoro, Kenji; Yonetoku, Yasuhiro; Moritomo, Ayako; Hayakawa, Masahiko; Iikubo, Kazuhiko; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki. The article conveys some information:
A series of fused-pyrimidine derivatives has been discovered as potent and orally active GPR119 agonists. A combination of the fused-pyrimidine structure and 4-chloro-2,5-difluorophenyl group provided the 5,7-dihydrothieno[3,4-d]pyrimidine 6,6-dioxide derivative I as a highly potent GPR119 agonist. Further optimization of the amino group at the 4-position in the pyrimidine ring led to the identification of 2-{1-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperidin-4-yl}acetamide (II) as an advanced analog. Compound II was found to have extremely potent agonistic activity and improved glucose tolerance at 0.1 mg/kg po in mice. The authors consider compound II and its analogs to have clear utility in exploring the practicality of GPR119 agonists as potential therapeutic agents for the treatment of type 2 diabetes mellitus. In the experiment, the researchers used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Reference of 2-(Piperidin-4-yl)ethanol)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKReference of 2-(Piperidin-4-yl)ethanol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem