Action of new antihistaminics. Chemical constitution and pharmacological action of the derivatives of halogen-containing benzhydrylamine was written by Nakashima, Toshio;Hisada, Shiro. And the article was included in Nagoya Medical Journal in 1958.Name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride This article mentions the following:
Ten hydrochlorides and citrates of aminoethyl benzhydryl ethers substituted at the amino group as well as in the ring were investigated for antihistaminic (I), anticholinergic (II), myotropic spasmolytic, antihistamine-shock (III) activities and acute toxicity. Para-substitution of one phenyl ring with a halogen and substitution of the Me2N group with a morpholine radical increases III potency and reduces activity in isolated organs. Toxicities of F, Cl, and Br decrease in this order. Substitution of NMe2 by piperidine radicals lowers III potency, except para-substitution with F, and increases I and II activities in the isolated organ. p-Fluoro substitutions of diphenylhydramine are slightly more active and less toxic in the citrate than in the hydrochloride. In the experiment, the researchers used many compounds, for example, 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0Name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride).
1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem