Understanding the Conformational Behavior of Fluorinated Piperidines: The Origin of the Axial-F Preference was written by Nairoukh, Zackaria;Strieth-Kalthoff, Felix;Bergander, Klaus;Glorius, Frank. And the article was included in Chemistry – A European Journal in 2020.Recommanded Product: 3-Fluoropiperidine hydrochloride This article mentions the following:
Gaining an understanding of the conformational behavior of fluorinated compounds would allow for expansion of the current mol. design toolbox. In order to facilitate drug discovery efforts, a systematic survey of a series of diversely substituted and protected fluorinated piperidine derivatives has been carried out using NMR spectroscopy. Computational investigations reveal that, in addition to established delocalization forces such as charge-dipole interactions and hyperconjugation, solvation and solvent polarity play a major role. This work codifies a new design principle for conformationally rigid mol. scaffolds. In the experiment, the researchers used many compounds, for example, 3-Fluoropiperidine hydrochloride (cas: 737000-77-0Recommanded Product: 3-Fluoropiperidine hydrochloride).
3-Fluoropiperidine hydrochloride (cas: 737000-77-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Recommanded Product: 3-Fluoropiperidine hydrochloride
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem