Product Details of 1445-73-4In 2020 ,《Quinoline Based Monocarbonyl Curcumin Analogs as Potential Antifungal and Antioxidant Agents: Synthesis, Bioevaluation and Molecular Docking Study》 appeared in Chemistry & Biodiversity. The author of the article were Nagargoje, Amol A.; Akolkar, Satish V.; Siddiqui, Madiha M.; Subhedar, Dnyaneshwar D.; Sangshetti, Jaiprakash N.; Khedkar, Vijay M.; Shingate, Bapurao B.. The article conveys some information:
In search for new fungicidal and free radical scavenging agents, we synthesized a focused library of 2-chloroquinoline based monocarbonyl analogs of curcumin (MACs). The synthesized MACs were evaluated for in vitro antifungal and antioxidant activity. The antifungal activity was evaluated against five different fungal strains such as Candida albicans, Fusarium oxysporum, Aspergillus flavus, Aspergillus niger, and Cryptococcus neoformans, resp. Most of the synthesized MACs displayed promising antifungal activity compared to the standard drug Miconazole. Furthermore, mol. docking study on a crucial fungal enzyme sterol 14α-demethylase (CYP51) could provide insight into the plausible mechanism of antifungal activity. MACs were also screened for in vitro radical scavenging activity using butylated hydroxytoluene (BHT) as a standard Almost all MACs exhibited better antioxidant activity compared to BHT. After reading the article, we found that the author used 1-Methyl-4-piperidone(cas: 1445-73-4Product Details of 1445-73-4)
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Product Details of 1445-73-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem