One-pot conversion of alkyl aldehydes into substituted propanoic acids via Knoevenagel condensation with Meldrum’s acid was written by Mudhar, Harminder;Witty, Andrew. And the article was included in Tetrahedron Letters in 2010.Recommanded Product: 138163-08-3 This article mentions the following:
Reaction of a range of alkyl aldehydes and Meldrum’s acid in triethylammonium formate (TEAF) at 100°C generated substituted propanoic acids in a single step. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Recommanded Product: 138163-08-3).
Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 138163-08-3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem