Moustakim, Moses et al. published their research in Angewandte Chemie, International Edition in 2017 | CAS: 168466-85-1

(S)-1-Benzylpiperidin-3-amine (cas: 168466-85-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Synthetic Route of C12H18N2

Discovery of a PCAF Bromodomain Chemical Probe was written by Moustakim, Moses;Clark, Peter G. K.;Trulli, Laura;Fuentes de Arriba, Angel L.;Ehebauer, Matthias T.;Chaikuad, Apirat;Murphy, Emma J.;Mendez-Johnson, Jacqui;Daniels, Danette;Hou, Chun-Feng D.;Lin, Yu-Hui;Walker, John R.;Hui, Raymond;Yang, Hongbing;Dorrell, Lucy;Rogers, Catherine M.;Monteiro, Octovia P.;Fedorov, Oleg;Huber, Kilian V. M.;Knapp, Stefan;Heer, Jag;Dixon, Darren J.;Brennan, Paul E.. And the article was included in Angewandte Chemie, International Edition in 2017.Synthetic Route of C12H18N2 This article mentions the following:

The p300/CBP-associated factor (PCAF) and related GCN5 bromodomain-containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophys. characterization led to the discovery of the triazolopthalazine-based L-45 (dubbed L-Moses) as the first potent, selective, and cell-active PCAF bromodomain (Brd) inhibitor. Synthesis from readily available (1R,2S)-(-)-norephedrine furnished L-45 in enantiopure form. L-45 was shown to disrupt PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. Compound L-45 shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use. In the experiment, the researchers used many compounds, for example, (S)-1-Benzylpiperidin-3-amine (cas: 168466-85-1Synthetic Route of C12H18N2).

(S)-1-Benzylpiperidin-3-amine (cas: 168466-85-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Synthetic Route of C12H18N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem