Motika, Stephen E. published the artcileGram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch, Name: tert-Butyl piperidin-4-ylcarbamate, the main research area is antibiotic riboswitch ribocil.
Multidrug-resistant Gram-neg. (GN) infections for which there are few available treatment options are increasingly common. The development of new antibiotics for these pathogens is challenging because of the inability of most small mols. to accumulate inside GN bacteria. Using recently developed predictive guidelines for compound accumulation in Escherichia coli, we have converted the antibiotic Ribocil C, which targets the FMN (FMN) riboswitch, from a compound lacking whole-cell activity against wild-type GN pathogens into a compound that accumulates to a high level in E. coli, is effective against Gram-neg. clin. isolates, and has efficacy in mouse models of GN infections. This compound allows for the first assessment of the translational potential of FMN riboswitch binders against wild-type Gram-neg. bacteria.
Journal of the American Chemical Society published new progress about Acinetobacter baumannii. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Name: tert-Butyl piperidin-4-ylcarbamate.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem