Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 22990-77-8, Name is 2-Piperidylmethylamine, molecular formula is C6H14N2, belongs to piperidines compound, is a common compound. In a patnet, author is Roque, Jose B., once mentioned the new application about 22990-77-8, Recommanded Product: 22990-77-8.
Deconstructive diversification of cyclic amines
Deconstructive functionalization involves carbon-carbon (C-C) bond cleavage followed by bond construction on one or more of the constituent carbons. For example, ozonolysis(1) and olefin metathesis(2,3) have allowed each carbon in C=C double bonds to be viewed as a functional group. Despite the substantial advances in deconstructive functionalization involving the scission of C=C double bonds, there are very few methods that achieve C(sp(3))-C(sp(3)) single-bond cleavage and functionalization, especially in relatively unstrained cyclic systems. Here we report a deconstructive strategy to transform saturated nitrogen heterocycles such as piperidines and pyrrolidines, which are important moieties in bioactive molecules, into halogen-containing acyclic amine derivatives through sequential C(sp(3))-N and C(sp(3))-C(sp(3)) single-bond cleavage followed by C(sp(3))-halogen bond formation. The resulting acyclic haloamines are versatile intermediates that can be transformed into various structural motifs through substitution reactions. In this way we achieve the skeletal remodelling of cyclic amines, an example of scaffold hopping. We demonstrate this deconstructive strategy by the late-stage diversification of proline-containing peptides.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem