Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, molecular formula is C13H18FNO, belongs to piperidines compound. In a document, author is Ariffin, Eda Yuhana, introduce the new discover.
Synthesis and Characterization of Nickel(II) Salphen Complex with Piperidine Side Chain and Interaction Study with Dengue DNA
Development of DNA biosensor model based on interaction of metal complexes as DNA hybridization marker can be used for dengue viruses early diagnosis. Nickel(II) salphen complex with piperidine side chain were successfully synthesized and characterized using Nucleus Magnetic Resonance Spectroscopy (NMR), mass spectrometry, differential scanning calorimetry and FTIR. The binding mode and interactions of nickel(II) salphen complex with piperidine side chain and dengue DNA were determined by uv-vis titration. Based on ultra violet visible spectra, hypochromism and redshift (bathochromism) were observed after upon tiration of the complex with dengue DNA which suggested formation of new complex. Nickel(II) salphen complex with piperidine side chain interact with dengue DNA by intercalation binding mode with the binding constant, Kb= 4.576×10(5) M-1. This new finding is so valuable for developing nickel(II) salphen complex as DNA hybridization marker for DNA optical biosensor to determine dengue virus.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 105812-81-5. Application In Synthesis of (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem