Recently I am researching about N-ACYL KETIMINES; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; 1,3-DISUBSTITUTED ISOINDOLINES; STEREOSELECTIVE-SYNTHESIS; CATALYZED ARYLATION; MICHAEL REACTIONS; DIRECTING GROUP; 3+2 ANNULATION; ACTIVATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672192, U1904212, 21472176]. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, XH; Gong, JF; Song, MP. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(iii)-catalyzed chiral N-sulfinyl amide directed asymmetric [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramolecular aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. The absolute configurations of the newly formed C-stereocenters in the major and minor diastereomers of the catalysis product have been determined by X-ray crystal diffraction analysis to be S and R, respectively. The separation of the major diastereoisomers from the catalysis products and subsequent removal of the N-sulfinyl chiral auxiliary afforded enantiomerically pure (S)-isoindolinones. The application of the obtained (S)-isoindolinones in the synthesis of several biologically active isoindolinones such as (S)-PD172938, (S)-pazinaclone and (S)-pagoclone is presented.
Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Li, XH; Gong, JF; Song, MP or send Email.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem