Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Chemistry very interesting. Saw the article Robust Buchwald-Hartwig amination enabled by ball-milling published in 2019, Reprint Addresses Browne, DL (corresponding author), Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3EQ, S Glam, Wales.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.
An operationally simple mechanochemical method for the Pd catalysed Buchwald-Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.
About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Cao, Q; Nicholson, WI; Jones, AC; Browne, DL or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem