Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC AMINATION; TRANSFER HYDROGENATION; DIORGANOZINC REAGENTS; IMINES; AMINES; FLUORINE; ALKENES; ACCESS; ARYL, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP 15H05485, 18K19078, JP 17H06092]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Takata, T; Hirano, K; Miura, M. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.
Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Takata, T; Hirano, K; Miura, M or send Email.
Reference：
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