Preparation and atropisomerism of 1-(2-aryl)-piperidin-2-ones was written by Mohrle, H.;Jeandree, M.;Breitmaier, E.;Rohonczy, J.. And the article was included in Journal fuer Praktische Chemie (Weinheim, Germany) in 2000.Safety of 4,4-Dimethylpiperidine This article mentions the following:
Course and rate of the dehydrogenation of N-tertiary piperidines dependent on their substitution in 4-position and on the OH-bearing neighbor group were examined, using Hg(II)-EDTA and model piperidine-derived amino alcs. The results showed that increasing size of 4-substituents and neighbor groups too decreased the rate of reaction. The products from 2-substituted benzylic alcs., 2-piperidones demonstrated atropisomerism. In the case of chiral neighbor groups, diastereomeric mixtures were formed. In the experiment, the researchers used many compounds, for example, 4,4-Dimethylpiperidine (cas: 4045-30-1Safety of 4,4-Dimethylpiperidine).
4,4-Dimethylpiperidine (cas: 4045-30-1) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 4,4-Dimethylpiperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem