Synthesis, characterization and antimicrobial activity of substituted N-benzhydrylpiperidin-4-amine derivatives was written by Mittal, Manish;Sarode, Suraj M.;Shingare, Ramesh M.;Vidyasagar, G.;Shrivastava, Birendra. And the article was included in Journal of Chemical and Pharmaceutical Research in 2011.Application of 33439-27-9 This article mentions the following:
N-benzhydrylpiperidin-4-amine derivatives were synthesized by reductive amination of benzhydrylamine and N-Substituted 4-piperidones as the starting material. The structures of all the synthesized compoundswere determined by their spectral and microanal. data. All the synthesized products were evaluated for their anti-bacterial activity against Bacillus substilis, Escherichia coli, Klebsiella pneumoniae and Streptococcus aureus bacteria and anti-fungal activity against Aspergillus niger, Aspergillus flavus, fungi resp. Most of the synthesized compounds exhibited significant antibacterial and antifungal activities. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Application of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Application of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem