In situ approach for testing the enantiopurity of chiral amines and amino alcohols by 1H NMR was written by Mishra, Sandeep Kumar;Chaudhari, Sachin R.;Suryaprakash, N.. And the article was included in Organic & Biomolecular Chemistry in 2014.Formula: C6H13N This article mentions the following:
An in situ approach involving a simple mix and shake method for testing the enantiopurity of primary, secondary and tertiary chiral amines and their derivatives, chiral amino alcs., by 1H-NMR spectroscopy is developed. The protocol involves the in situ formation of chiral ammonium borate salt from a mixture of C2 sym. chiral BINOL, trialkoxyborane and chiral amines. The proposed concept was demonstrated convincingly on a large number of chiral and pro-chiral amines and amino alcs., and also aids the precise measurement of enantiomeric excess. The protocol can be completed in a couple of minutes directly in the NMR sample tube, without the need for any phys. separation In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Formula: C6H13N).
(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Formula: C6H13N
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem