On January 18, 2018, Mellstedt, Haakan; Bystroem, Styrbjoern; Vaagberg, Jan; Olsson, Elisabeth published a patent.Related Products of 357935-97-8 The title of the patent was 2-Phenylimidazo[4,5-B]pyridin-7-amine derivatives used as inhibitors of mammalian tyrosine kinase ROR1 activity and their preparation. And the patent contained the following:
The invention provides compounds of formula I and II and their use as inhibitors of mammalian tyrosine kinase ROR1. Compounds of formula I and II, wherein R1 is C1-6 alkyl, C3-6 cycloalkyl-C1-6 alkyl, cyano-C1-6 alkyl, etc.; Ra is independently C1-6 alkyl; x is 0, 1, 2, 3 and 4; m is 1 and 2; R2 is Cl and Br; Rb is halo, C1-3 alkyl and C1-3 alkoxy; y is 0, 1, 2 and 3; W is QR4, O and N(R5)CO; Q is N and CH; R4 is C1-6 alkyl, cyano-C1-6 alkyl, C1-6 alkyl-SO2, etc.; Z is N and CH; R3 is independently C1-6 alkyl; p is 0, 1, 2 and 3; n is 0, 1 and 2; and pharmaceutically acceptable salt thereof, are claimed. Compound III was prepared by a multistep procedure (procedure given). Compounds were tested for mammalian tyrosine kinase ROR1 inhibitory activity (data given). The experimental process involved the reaction of 1-Ethylpiperidin-4-amine dihydrochloride(cas: 357935-97-8).Related Products of 357935-97-8
The Article related to imidazole pyridine derivative preparation ror1 inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Related Products of 357935-97-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem