Investigation of the scope of an enantioselective Co-mediated O→C rearrangement reaction was written by Meek, Simon J.;Demont, Emmanuel H.;Harrity, Joseph P. A.. And the article was included in Tetrahedron Letters in 2007.Formula: C12H15NO3S This article mentions the following:
A series of enantiomerically enriched functionalized pyrans bearing a dicobalt hexacarbonyl-alkyne moiety were subjected to a Lewis acid-mediated rearrangement to carbocyclic ketones. This process was found to provide cyclohexanones with good enantioselectivity, however, cyclobutanones were generated with complete loss of enantiocontrol. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Formula: C12H15NO3S).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Formula: C12H15NO3S
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem