Development of the Scope of a Co-Mediated O閳墫 Rearrangement Reaction was written by Meek, Simon J.;Pradaux, Fabienne;Carbery, David R.;Demont, Emmanuel H.;Harrity, Joseph P. A.. And the article was included in Journal of Organic Chemistry in 2005.Application of 33439-27-9 This article mentions the following:
An Al-promoted, Co-mediated O閳墫 rearrangement reaction of cyclic enol ethers is described. This process delivers functionalized cyclohexanones with good to excellent levels of diastereo control, whereby the product stereochem. is dependent on the E/Z-stereochem. of the starting enol ether. The rearrangement process also permits access to highly substituted 浼?spirocyclic cyclohexanones as well as cyclopentanones. The latter rearrangement appears to proceed via an unusual 5-(enol-endo)-exo-trig cyclization process. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Application of 33439-27-9).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 33439-27-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem