Direct and enantioselective α-allylation of ketones via singly occupied molecular orbital (SOMO) catalysis was written by Mastracchio, Anthony;Warkentin, Alexander A.;Walji, Abbas M.;MacMillan, David W. C.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2010.Category: piperidines This article mentions the following:
The first enantioselective organocatalytic α-allylation of cyclic ketones was accomplished via singly occupied MO catalysis. Geometrically constrained radical cations, forged from the one-electron oxidation of transiently generated enamines, readily undergo allylic alkylation with a variety of com. available allylsilanes. A reasonable latitude in both the ketone and allylsilane components is readily accommodated in this new transformation. Moreover, three new oxidatively stable imidazolidinone catalysts have been developed that allow cyclic ketones to successfully participate in this transformation. The new catalyst platform has also been exploited in the first catalytic enantioselective α-oxoalkylation and α-arylalkylation of ketones. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Category: piperidines).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem