Mao, Jialin et al. published their research in ChemMedChem in 2007 | CAS: 118753-66-5

tert-Butyl 4-aminopiperazine-1-carboxylate (cas: 118753-66-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Related Products of 118753-66-5

Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents was written by Mao, Jialin;Wang, Yuehong;Wan, Baojie;Kozikowski, Alan P.;Franzblau, Scott G.. And the article was included in ChemMedChem in 2007.Related Products of 118753-66-5 This article mentions the following:

Tuberculosis (TB) is presently regarded as one of the most dangerous infective diseases worldwide and one of the major AIDS-associated infections. To shorten the current treatment regimen, there is an urgent need to identify new anti-TB agents which are active against both replicating TB (R-TB) and nonreplicating TB (NRP-TB). Mefloquine, a well-known antimalarial drug was found to possess reasonable activity against NRP-TB, and accordingly, 30 new analogs were synthesized and evaluated for their anti-TB activity against Mycobacterium tuberculosis H37Rv. As the target of mefloquine in Mycobacterium tuberculosis remains unknown, we resorted to modifying mefloquine in a variety of chem. convenient ways, which led us in turn to the active hydrazone 10a. Further modifications of 10a led to compound 7f, with an improved anti-TB activity/selectivity profile with both less cytotoxicity and less predicted CNS side effects compared with mefloquine. The clear structure-activity relationships (SARs) derived from this study should facilitate our ultimate goal of identifying improved anti-TB agents. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-aminopiperazine-1-carboxylate (cas: 118753-66-5Related Products of 118753-66-5).

tert-Butyl 4-aminopiperazine-1-carboxylate (cas: 118753-66-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Related Products of 118753-66-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem