Malesevic, Miroslav published the artcileAn improved method for the solution cyclization of peptides under pseudo-high dilution conditions, Application In Synthesis of 158922-07-7, the main research area is cyclopeptide solid phase synthesis; macrocyclization solid phase solution pseudo high dilution.
Depending on the ring size, the cyclization of peptides often is accompanied by dimerization or cyclodimerization. Hence, these macrocyclizations have to be performed under high dilution conditions. Efficient cyclization of peptides in solution with a min. amount of solvent succeeds, when a dual syringe pump is used to simultaneously add the linear peptide precursor and a coupling reagent from two sep. syringes.
Journal of Biotechnology published new progress about Dilution. 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, Application In Synthesis of 158922-07-7.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem