On September 14, 2017, Mainolfi, Nello; Moyer, Mikel P. published a patent.Electric Literature of 362703-57-9 The title of the patent was Indole-2-carboxamides as 3-phosphoglycerate dehydrogenase inhibitors and their preparation. And the patent contained the following:
The invention provides compoundsof formula I, compositions thereof, and methods of using the same. Compounds of formula I wherein R1 and R6 are independently H, C1-4 alkyl; R2 and R3 are independently halo, CN, (un)substituted C1-6 aliphatic, etc.; R4 is H, halo, CN, etc.; R8 os H, CO2H and derivs and (un)substituted C1-6 aliphatic group; R9 is H, halo and (un)substituted C1-4 alkyl; A is (un)saturated 3- to 8-membered carbocyclyl, (un)substituted 7- to 12-membered bicyclic carbocyclyl, (un)saturated 4- to 8-membered heterocyclyl, etc.; L1 is a bond and (un)branched C1-6 bivalent hydrocarbon chain wherein 1 to 5 methylene units may be replaced with O, CO, CO2, etc.; n is 0, 1, 2, 3, 4 and 5; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their PHGDH inhibitory activity (data given). The experimental process involved the reaction of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate(cas: 362703-57-9).Electric Literature of 362703-57-9
The Article related to indole carboxamide 3phosphoglycerate dehydrogenase inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Electric Literature of 362703-57-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem