Application In Synthesis of (S)-1-tert-Butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylateOn June 10, 1996, Machetti, Fabrizio; Cordero, Franca M.; De Sarlo, Francesco; Guarna, Antonio; Brandi, Alberto published an article in Tetrahedron Letters. The article was 《Rearrangement of isoxazolidine 5-spiro derivates. 13. A new synthesis of (2S)-4-oxopipecolic acid by thermal rearrangement of enantiopure spirocyclopropaneisoxazolidine》. The article mentions the following:
A novel synthesis of (2S)-4-oxopipecolic acid is reported. The synthetic route employs as a key step the diastereoselective cycloaddition of the N-glycosylnitrone I to methylenecyclopropane followed by thermal rearrangement of the spirocyclopropaneisoxazolidine II. Stereoselective reduction of the N-Boc 4-oxopipecolic acid Et ester by L-selectride gives the protected cis-4-hydroxypipecolic acid III. The experimental part of the paper was very detailed, including the reaction process of (S)-1-tert-Butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylate(cas: 180854-44-8Application In Synthesis of (S)-1-tert-Butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylate)
(S)-1-tert-Butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylate(cas: 180854-44-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Application In Synthesis of (S)-1-tert-Butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem