Luo, Zonghua published the artcileSynthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer’s Disease Based on the Fusion of Donepezil and Ebselen, COA of Formula: C6H12N2O, the publication is Journal of Medicinal Chemistry (2013), 56(22), 9089-9099, database is CAplus and MEDLINE.
Benzylpiperidinylalkyl benzoisoselenazolones I [R = H, MeO; R1 = H, Cl, F, MeO; X = (CH2)n; n = 1-4] were prepared as donepezil-ebselen hybrids for potential use as anti-Alzheimer’s disease agents. I (R = R1 = MeO; n = 2) was one of the most potent acetylcholinesterase inhibitors of the compounds tested (IC50 values of 0.042 μM for Electrophorus electricus acetylcholinesterase and 0.097 μM for human acetylcholinesterase) and was found to be a strong butyrylcholinesterase inhibitor with an IC50 value of 1.586 μM, to possess rapid H2O2 and peroxynitrite scavenging activity and glutathione peroxidase-like activity (ν0 = 123.5 μM min-1), and to be a substrate of mammalian thioredoxin reductase. I (R = R1 = MeO; n = 2) showed no acute toxicity at doses of up to 2000 mg/kg; by comparing its permeation in an artificial blood-brain barrier permeation assay, I (R = R1 = MeO; n = 2) was expected to be able to penetrate the central nervous system.
Journal of Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, COA of Formula: C6H12N2O.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem