Enantioselective Preparation of Arenes with 尾-Stereogenic Centers: Confronting the 1,1-Disubstituted Olefin Problem Using CuH/Pd Cooperative Catalysis was written by Lu, Zhaohong;Buchwald, Stephen L.. And the article was included in Angewandte Chemie, International Edition in 2020.Product Details of 57356-64-6 This article mentions the following:
Arenes with 尾-stereogenic centers are important substructures in pharmaceuticals and natural products. We have developed an asym. anti-Markovnikov hydroarylation of 1,1-disubstituted olefins by dual palladium and copper hydride catalysis as a convenient and general approach to access these substructures. This efficient one-step process addresses several limitations of the traditional stepwise approaches. The use of cesium benzoate as a base and a common phosphine ligand for both the Cu- and Pd-catalyzed processes were important discoveries that allow these challenging olefin substrates to be efficiently transformed. A variety of aryl bromide coupling partners, including numerous heterocycles, were coupled with 1,1-disubstituted alkenes to generate arenes with 尾-stereogenic centers. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-(piperidin-1-yl)pyrimidine (cas: 57356-64-6Product Details of 57356-64-6).
5-Bromo-2-(piperidin-1-yl)pyrimidine (cas: 57356-64-6) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Product Details of 57356-64-6
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem