On July 23, 2020, Looper, Ryan E.; Sebahar, Paul; Reddy, Hariprasada R. Kanna; Haussener, Travis J.; Testa, Charles A.; Tresco, Benlsaac C.; Grant, Seth; Napolitano, Carmela; Sabbatini, Fabio Maria published a patent.Formula: C13H24N2O2 The title of the patent was Preparation of cytosine derivatives as antimicrobial agents. And the patent contained the following:
The invention is directed to compounds I [Z = C(O), C(S), S(O), etc.; ring A = (un)substituted monocyclic heterocycloalkylene or bicyclic heterocycloalkylene; J = absent, (un)substituted alkylene, heterocycloalkylene, etc.; X1 and X2 = (independently) CH or N; Y = (un)substituted linear alkylene, alkenylene, or alkynylene; ring B = (un)substituted monocyclic cycloalkylene or monocyclic heterocycloalkylene; L = absent, or alkylene, wherein up to two methylene units may independently be replaced with O, NH, C(O), etc.; R1 = H, halo, haloalkyl, etc.; R11 = H or (un)substituted NH2; R2 and R3 = (independently) alkyl, halo, CN, etc.; m and n = (independently) 0-3] or pharmaceutically acceptable salts thereof, that are active as antibacterial agents. E.g., a 2-step synthesis of trans-II, starting from tert-Bu (1-(4-((1-(4-formylphenyl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)piperazin-1-yl)-2-methyl-1-oxopropan-2-yl)carbamate and N-Boc-trans-1,4-cyclohexanediamine, was described. Biol. activity of compounds I was determined (data given). The invention compounds I are active against gram-pos. and gram-neg. bacteria and can be used to treat infections caused by gram-pos. and gram-neg. bacteria. Also disclosed are processes and intermediates for making the compounds I. The experimental process involved the reaction of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate(cas: 1251006-64-0).Formula: C13H24N2O2
The Article related to cytosine aminopyrimidinone derivative preparation antibacterial antimicrobial, gram pos neg bacteria infection cytosine aminopyrimidinone derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C13H24N2O2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem