An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs was written by Lin, Pei-Ying;Chang, Yu-Jung;Chen, Yu-Chen;Lin, Chin-Hung;Erkekoglu, Pinar;Chao, Ming-Wei;Tseng, Chia-Yi. And the article was included in PLoS One in 2018.Reference of 316-81-4 This article mentions the following:
Here we report a novel multi-methodol. approach to identify opportunities for drug repositioning. We performed analyses of real-world data (RWD) acquired from the FAERS and the claims database maintained by the JMDC. These analyses were followed by cross-validation through bioinformatics analyses of gene expression data. Inverse associations revealed using DPA and SSA were used to detect potential drug-repositioning signals. To evaluate the validity of the approach, we conducted a feasibility study to identify marketed drugs with the potential for treating inflammatory bowel disease (IBD). Primary analyses of the FAERS and JMDC claims databases identified psycholeptics such as haloperidol, diazepam, and hydroxyzine as candidates that may improve the treatment of IBD. To further investigate the mechanistic relevance between hit compounds and disease pathol., we conducted bioinformatics analyses of the associations of the gene expression profiles of these compounds with disease. We identified common biol. features among genes differentially expressed with or without compound treatment as well as disease-perturbation data available from open sources, which strengthened the mechanistic rationale of our initial findings. Integrative anal. of RWD such as those available from adverse-event databases, claims databases, and transcriptome analyses represent an effective approach that adds value to efficiently identifying potential novel therapeutic opportunities. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Reference of 316-81-4).
N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Reference of 316-81-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics